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ea0041ep1098 | Thyroid cancer | ECE2016

Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene

Urnauer Sarah , Morys Stephan , Levacic Ana Krhac , Muller Andrea M , Schug Christina , Schmohl Kathrin A , Schwenk Nathalie , Zach Christian , Carlsen Janette , Bartenstein Peter , Wagner Ernst , Spitzweg Christine

The sodium iodide symporter (NIS) in its role as well characterized reporter and therapy gene represents an outstanding tool to target different cancer types allowing non-invasive imaging of functional NIS expression by 123I-scintigraphy and therapeutic application of 131I. Based on its overexpression on the surface of the vast majority of cancer types, the cMET/Hepatocyte growth factor receptor (HGFR) serves as an ideal target for tumor-selective gene de...

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Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene

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